Biography

Dr Alexander Lyon is an honorary consultant cardiologist at Royal Brompton & Harefield Hospitals Specialist Care, where he treats private patients. 

Dr Lyon studied at the University of Oxford, then trained as a junior doctor in cardiology in Oxford, in London (at Royal Brompton Hospital) and in Sydney, Australia.

He joined the cardiac medicine research group of Professor Sian Harding and Professor Philip Poole-Wilson, where he studied the influence of cardiac gene therapy upon ventricular arrhythmia generation. In 2005, he was awarded an MRC Clinical Research Training Fellowship.

Shortly later he completed his PhD in 2008, and spent his first postdoctoral year studying the spatiotemporal patterns of mitochondrial function in the lab of Fadi Akar and Roger Hajjar at Mount Sinai School of Medicine, New York.

In 2008, he was appointed a Walport Clinical Lecturer in Cardiology at Imperial College London, and completed his cardiology training at St Mary’s Hospital and Royal Brompton Hospital.

In 2012, Dr Lyon was appointed a senior lecturer and consultant cardiologist at Royal Brompton Hospital.

Dr Lyon has received a number of academic awards throughout his career, including the: 

  • British Society for Cardiovascular Research - Bernard and Joan Marshall Young Investigator Prize (2010)

  • British Cardiovascular Society - Young Investigator Competition Winner (Basic Sciences) (2009)

  • Medical Research Society - Raftery Prize in Cardiovascular Sciences Winner (2008)

  • International Society of Heart Research (European meeting) - Best Scientific Poster Prize (2008)

  • Royal Society of Medicine (cardiology section) - President’s Medal Winner (2007).

Clinical expertise

Dr Alexander Lyon's clinical expertise includes:

  • heart failure
  • cardiovascular diseases caused by cancer treatments, known as cardio-oncology
  • chemotherapy-induced heart failure
  • Takotsubo syndrome
  • cardiac gene therapy
  • novel molecular and biological therapies for heart failure.

He runs a specialist clinic for patients with Takotsubo syndrome focusing on risk prediction and management of refractory symptoms.

He is also:

  • clinical lead for the cardio-oncology service, Royal Brompton Hospital (2011-present)
  • chair of UK Cardio-Oncology Consortium (2012- present)
  • a member of Heart Failure Association Translational Research Committee (ESC: 2012-present).

He sees patients with a range of clinical problems including:

Dr Lyon also specialises in the investigation of cardiac symptoms such as chest pain, breathlessness, palpitations (racing heart), dizzy spells and general cardiac health checks to guide risk factor management.

Research interests

Dr Alexander Lyon is a co-investigator at the BHF Centre for Cardiovascular Regenerative Medicine at Imperial College London. In addition, he is the lead for the heart failure research theme of the National Institute of Health Research (NIHR) cardiovascular biomedical research unit (cBRU) at Royal Brompton Hospital.

Dr Lyon's research interests include:

  • abnormal calcium physiology in heart failure
  • the influence of stress and high catecholamine levels on cardiac function
  • mechanisms of ventricular arrhythmias in heart failure
  • biological therapies for heart failure – these include gene therapy, stem cell therapy and myocardial tissue engineering. Dr Lyon is UK national coordinating investigator for CUPID 2 - the first UK cardiac gene therapy trial for advanced heart failure.
  • RDT-PEF trial assessing the role of renal sympathetic denervation in patients with heart failure and preserved ejection fraction
  • spatio-temporal patterns of mitochondrial dysfunction in the intact heart
  • chemotherapy-induced heart failure and novel therapeutic options for patients with heart failure caused by anti-cancer therapies - Dr Lyon was a co-Principal Investigator
  • new high resolution raspberry Pi multi camera system for remote monitoring of leg oedema in heart failure patients with Heartfelt Technologies.

He is coordinating both a national and European strategy to advance knowledge and improve care for individuals with Takotsubo syndrome.

Watch Dr Lyon discuss Trust research into exploring the role of gene therapy in helping treat people with heart and lung diseases:

Publications

Dr Alexander Lyon has reviewed manuscripts for various scientific journals including:

  • British Medical Journal
  • Circulation Research
  • European Heart Journal, Heart
  • European Journal of Heart Failure
  • American Journal of Physiology
  • British Journal of Pharmacology
  • Europace
  • Journal of Cardiac Failure
  • Cardiology
  • Progress in Neuro-Psychopharmacology & Biological Psychiatry and Medical Science Monitor.

Teaching

Dr Alexander Lyon has presented at numerous national and international meetings in the field of cardiac calcium pathophysiology, gene therapy in heart failure, chemotherapy-induced cardiac dysfunction and heart failure, and Takotsubo cardiomyopathy. 

He is a senior lecturer at Imperial College London, where he supervises PhD students.